Recently I encountered the acronym ANADEW, which I found to mean A natlang's already dunnit, except worse. Pondering a comment from Logan R. Kearsley where he speculated that "... it's mildly positive in naturalistic circles, since if a natlang already does it, you know you're justified in using it." I began to wonder what did not eventually fit in the ANADEW concept.
I gather that Lojban might be unique in its strong attention to being logical, as explained in two excellent answers to What makes lojban such a “logical” language?. If it is not unique, at least it still is something that I don't thing any natlang has as a strong point.
In the short time that this site's been open, it has struck me that conlangs might be improvements in one way or another over natlangs, yet despite their diversity, they haven't matched the diversity, and utility, of natlangs.
So, what I'm wondering is, other than Lojban and its "logic" is there some other significant traits that some human conlang has which is not found in a natlang somewhere?
I wouldn't consider using never-before-heard sounds as significant, though that's been mentioned in another question. I would have considered having a super minimal verb set significant, as in Kēlen, except that, well ANADEW, or in this case maybe better.
Full disclosure, I am not a conlanger, likely never will be. Nonetheless, I find many fields interesting, and created languages is one of them. With that in mind, please excuse some of my oversights or misconstrued concepts.